This excerpt is from Success, Your Path to a Successful Book, by Maralyn D. Hill and Brenda C. Hill.
Do a search on http://www.amazon.com/ and determine how many books are listed in your category.

When your topic covers more than one category, i.e., food and travel, pick the category that fits your book best for placement and be sure your title leads with that category.

If your book falls into more than one category, the bookstores will not know where to place it.

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Maralyn D. Hill and Brenda C. Hill